Characterizing the cellular and humoral immune responses to Tdap during pregnancy compared to non-pregnant controls

Abstract Maternal Tdap vaccination during pregnancy is recommended to protect infants from pertussis, pre-vaccination. However, it unclear whether maternal immune responses improve following booster. We present analysis of pre- and post-Tdap booster, pregnant women (Pw) primed by whole cell vaccines, who received booster pregnancy, compared boosted non-pregnant (NPw). antigen specific serum antibody reactivity avidity increased in both groups. Reactivity were higher NPw Pw. Activation-induced marker assay peripheral blood revealed that pertussis Tmem cells Pw NPw. After the percentage CD4+CD25+OX40+ T was approximately 2.5-fold In contrast, proportion CD4+CD25+PDL1+ post-booster 3-fold NPw, suggesting may elevate Tregs Interim suggests increases responses, although magnitude phenotype differ between NPW. Antibody function, race related profiles, detailed phenotyping are progress.